People vary widely in ability to eliminate arsenic from the body
Public release date: 26-Aug-2009
Contact: Michael Woods
m_woods@acs.org 202-872-6293
American Chemical Society
Large variations exist in peoples' ability to eliminate arsenic from the body, according to a new study that questions existing standards for evaluating the human health risks from the potentially toxic substance. The study found that some people eliminate more than 90 percent of the arsenic consumed in the diet. Others store arsenic in their bodies, where it can have harmful effects. The research, based on the first application of new methods for studying arsenic, is scheduled for the Sept. 21 issue of ACS's Chemical Research in Toxicology, a monthly journal.
In the study, Kevin Francesconi and colleagues point out that drinking water in many parts of the world, including some regions of the United States, contain amounts of arsenic that exceed the World Health Organization's maximum acceptable levels. Consumption of seafood, the article notes, is another major source of arsenic contamination. Health effects from chronic arsenic exposure include skin and internal cancers, cardiovascular disease, and possibly diabetes, it adds.
The scientists describe monitoring arsenic excretion in the urine of human volunteers. They found that ability to eliminate arsenic from the body varied greatly, with some participants excreting up to 95 percent of the ingested arsenic but
others eliminating as little as four percent. "This observed individual variability in handling [arsenic] exposure
has considerable implications for the risk assessment of arsenic ingestion," the paper states. It adds that further study is needed to assess potential risks to humans consuming seafood products. "The data presented here suggest that the long held view that seafood arsenic is harmless because it is present mainly as organoarsenic compounds needs to be reassessed."
###
ARTICLE #2 FOR IMMEDIATE RELEASE
"Individual Variability in the Human Metabolism of an Arsenic-Containing Carbohydrate, 2',3'-Dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-ß-D-riboside, a Naturally Occurring Arsenical in Seafood"
DOWNLOAD FULL TEXT ARTICLE:
http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/tx900158h CONTACT:
Kevin Francesconi, Ph.D.
Karl-Franzens University Graz
Graz, Austria
Phone: 43 316 380 5301
Email:
kevin.francesconi@uni-graz.at http://www.eurekalert.org/pub_releases/2009-08/acs-pvw082609.php# posted by
Deborah Elaine Barrie
4 Catherine Street
Smiths Falls, On
Canada
K7A 3Z8
(613)284-8259
deborah@noccawood.ca http://www.noccawood.ca subscribe to list service at website
http://twitter.com/deborahbarrie What we do for ourselves dies with us. What we do for others and the world remains and is immortal.
Albert Pine
------------------------------------------
To unsubscribe, click here:
http://www.noccawood.ca/cgi-scripts/csNewsletter/csNewsletter.cgi?command=unsubscribe&email=x.heather@gmail.com,&list=noccawood